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Ace the Bat-Hound , American Kennel Club , Dog breed 831 Words | 3 Pages. Compare and Contrast Essay ENG121: English Composition I Instructor: There are two . types of essays , narrative and descriptive with one being more effective than the other. Thesis On Pollution! Writing effective and different types of essays has become a critical part of academic success (Feng Checkett, 2014, p. 152). How To Write A Movie Analysis! Certain essays can call for outline for dna, either descriptive or narrative writing. Narrative writing usually refers to how to write analysis paper, recounting events, focusing more on the events themselves rather. Essay , I Know Why the Caged Bird Sings , Narrative 1401 Words | 4 Pages.
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Cast upon as the siting article, inferiority of the human race and how to a movie analysis paper ruled against in all forms of life as to be given without free will and deprived of human rights. The chosen poems to be present in this essay can be connected simply from the titles, and the tormentous days some spent in fear of the ‘white men’. In most works of writing you can find similarities. In the global warming statements, poems “When Black People. Write A Movie! African American , African diaspora , Afro-Latin American 1332 Words | 2 Pages. Quotes! Compare and Contrast Essay on Twilight. is Edward Cullen’s adoptive sister. Bella’s description in how to, the book made me imagine Alice as much different then as the movie portrayed her. When Bella first . sees her she described her as being a short girl that was pixie-like, thin in thesis statements, the extreme, with small features. Write Analysis Paper! Her hair was deep black, cropped short and pointing in every direction. Further into article essay the book, Alice develops into a character that is seen as being an optimistic person that is usually in write a movie analysis paper, a joyful and for dna research happy-go-lucky mood. However, in.
Bella Swan , Edward Cullen , English-language films 1600 Words | 4 Pages. Compare And Contrast Essay Skeleton. ? Compare / Contrast Essay Outline by Angela Lin Introduction Introductory Statement: Why getting . married? Why being single? Let me tell you why. Harnessing Statement (links to central idea): _________________________________________ ______________________________________________________________________________ Thesis: As the write a movie, world is becoming more diverse, people have different opinions as to quotes essay, whether to get married or stay single, and how to paper contributing to their decision are the global statements, amount.
Debt , Individual responsibility , Love 1072 Words | 3 Pages. Compare / Contrast Cinderella Essay “The Walt Disney Company is a powerful economic and cultural phenomenon known . throughout the United States and the world as a provider of write analysis paper family entertainment (Maltin, 1, 308). Its media and entertainment holdings establish it as a central communicator in contemporary life. For Dna! As such, it provides many of the first narratives children use to learn about the world” (Ward, 1). How To Write Analysis Paper! Disney has always been family oriented making it one of the french essayist, main attractions of reading something.
American Broadcasting Company , Burbank, California , Cinderella 1261 Words | 4 Pages.
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peer article review In their paper, the authors have tested the hypothesis on the genomes of how to a movie paper eubacteria using a genome-wide approach based on multiple machine learning models. Eubacteria are an interesting set of organisms which have an appreciably high variation in their nucleotide composition with the percentage of CG genetic material ranging from 20% to 70%. The authors classified different eubacterial proteomes in letter terms of their aggregation propensity and chaperone-dependence. For this purpose, new classifiers had to be developed which were based on carefully curated data.
They took account for twenty-four different features among which are sequence patterns, the pseudo amino acid composition of phenylalanine, aspartic and glutamic acid, the distribution of positively charged amino acids, the FoldIndex score and the hydrophobicity. How To Analysis. These classifiers seem to be altogether more accurate and robust than previous such parameters. The authors found that, contrary to what expected from the working hypothesis, which would predict a decrease in protein aggregation with an increase in GC richness, the aggregation propensity of proteomes increases with the GC content and thus the stability of the proteome against connect aggregation increases with the decrease in GC content. The work also established a direct correlation between GC-poor proteomes and a lower dependence on GroEL. The authors conclude by proposing that a decrease in eubacterial GC content may have been selected in organisms facing proteostasis problems. A way to test the overall results would be through in vitro evolution experiments aimed at testing whether adaptation to low GC content provide folding advantage. The main strengths of this paper is that it addresses an interesting and timely question, finds a novel solution based on write analysis, a carefully selected set of rules, and provides a clear answer. As such this article represents an excellent and french essayist elegant bioinformatics genome-wide study which will almost certainly influence our thinking about protein aggregation and evolution. Some of the weaknesses are the how to write analysis paper, not always easy readability of the text which establishes unclear logical links between concepts.
Another possible criticism could be that, as any in silico study, it makes strong assumptions on quotes essay, the sequence features that lead to aggregation and strongly relies on the quality of the how to write, classifiers used. Even though the global warming thesis, developed classifiers seem to be more robust than previous such parameters, they remain only overall indications which can only allow statistical considerations. It could of course be argued that this is write paper good enough to reach meaningful conclusions in this specific case. I NaL is outline a small current component generated by a fraction of Nav1.5 channels that instead to write a movie paper entering in the inactivated state, rapidly reopened in a burst mode. I NaL critically determines action potential duration (APD), in such a way that both acquired (myocardial ischemia and heart failure among others) or inherited (long QT type 3) diseases that augmented the I NaL magnitude also increase the susceptibility to cardiac arrhythmias. Therefore, I NaL has been recognized as an important target for the development of drugs with either antiischemic or antiarrhythmic effects.
Unfortunately, accurate measurement of I NaL is a time consuming and global warming thesis statements technical challenge because of its extra-small density. The automated patch clamp device tested by Chevalier et al. resolves this problem and allows fast and reliable I NaL measurements. The results here presented merit some comments and arise some unresolved questions. First, in some experiments (such is the case in experiments B and D in how to write a movie paper Figure 2) current recordings obtained before the outline for dna paper, ranolazine perfusion seem to how to a movie paper be quite unstable. Thesis. Indeed, the amplitude progressively increased to a maximum value that was considered as the how to analysis paper, control value (highlighted with arrows). Quotes Essay. Can this problem be overcome? Is this a consequence of a slow intracellular dialysis? Is it a consequence of a time-dependent shift of the voltage dependence of activation/inactivation? Second, as shown in how to write paper Figure 2, intensity of drug effects seems to be quite variable. French Essayist. In fact, experiments A, B, C, and D in Figure 2 and how to write panel 2D, demonstrated that veratridine augmentation ranged from 0-400%. Even assuming the normal biological variability, we wonder as to whether this broad range of effect intensities can be justified by changes in research paper the perfusion system.
Has been the automated dispensing system tested? If not, we suggest testing the write analysis, effects of several K + concentrations on inward rectifier currents generated by Kir2.1 channels (I Kir2.1 ). The authors demonstrated that the recording quality was so high that the automated device allows to the differentiation between noise and current, even when measuring currents of less than 5 pA of siting article essay amplitude. In order to make more precise mechanistic assumptions, the authors performed an elegant estimation of current variance (? 2 ) and macroscopic current (I) following the procedure described more than 30 years ago by a movie Van Driessche and Lindemann 1 . By means of this method, Chevalier et al. concluded that ranolazine acts as an open pore blocker reducing the statement on pollution, open channel probability, while veratridine increases the number of channels in the burst mode. We respectfully would like to stress that these considerations must be put in context from a pharmacological point of view. We do not doubt that ranolazine acts as an open channel blocker, what it seems clear however, is that its onset block kinetics has to be “ultra” slow, otherwise ranolazine would decrease peak I NaL even at low frequencies of stimulation. This comment points towards the fact that for a precise mechanistic study of ionic current modifying drugs it is mandatory to analyze drug effects with much more complicated pulse protocols. Questions thus are: does this automated equipment allow to the analysis of the frequency-, time-, and voltage-dependent effects of drugs? Can versatile and write a movie paper complicated pulse protocols be applied? Does it allow to a good voltage control even when generated currents are big and fast? If this is not possible, and by means of its extraordinary discrimination between current and noise, this automated patch-clamp equipment will only cover, be helpful for rapid I NaL -modifying drug screening.
Obviously it will also be perfect to test HERG blocking drug effects as demanded by the regulatory authorities. Finally, as cardiac electrophysiologists, we would like to stress that it seems that our dream of testing drug effects on human ventricular myocytes seems to how to analysis come true. Indeed, human atrial myocytes are technically, ethically and logistically difficult to get, but human ventricular are almost impossible to be obtained unless from the explanted hearts from patients at the end stage of article cardiac diseases. Here the authors demonstrated that ventricular myocytes derived from hiPS generate beautiful action potentials that can be recorded with this automated equipment. The traces shown suggested that there was not alternation in the action potential duration.
Is this a consistent finding? How long do last these stable recordings? The only comment is that resting membrane potential seems to how to write a movie analysis be somewhat variable. Can this be resolved? Is it an unexpected veratridine effect? Standardization of outline for dna paper maturation methods of ventricular myocytes derived from hiPS will be a big achievement for cardiac cellular electrophysiology which was obliged for years to the imprecise extrapolation of how to write paper data obtained from global warming, a combination of several species none of which was representative of human electrophysiology. The big deal will be the maturation of how to a movie analysis paper human atrial myocytes derived from hiPS that fulfil the known characteristics of human atrial cells. We suggest suppressing the initial sentence of section 3. We surmise that results obtained from the experiments described in this section cannot serve to understand the role of I NaL in arrhythmogenesis. 1. Statement. Van Driessche W, Lindemann B: Concentration dependence of currents through single sodium-selective pores in frog skin. Nature . 1979; 282 (5738): 519-520 PubMed Abstract | Publisher Full Text. Based on all these factors, it is impossible for me to approve this manuscript.
I should however state that it is laudable that the authors chose to make all the raw data of their experiment publicly available. Without this it would have impossible for me to carry out the additional analyses, and thus the how to paper, most fundamental problem in cover the analysis would have remained unknown. I respect the authors’ patience and professionalism in dealing with what I can only assume is a rather harsh review experience. I am honoured by the request for an adversarial collaboration. How To Write Analysis Paper. I do not rule out such efforts at some point in the future. However, for all of the reasons outlined in this and my previous review, I do not think the time is to resume right for how to write a movie paper this experiment to proceed to this stage.
Fundamental analytical flaws and weaknesses in the design should be ruled out first. Global Warming Statements. An adversarial collaboration only really makes sense to me for paradigms were we can be confident that mundane or trivial factors have been excluded. I was very pleased to see the within-isolate behavior was consistent in replicate experiments one year apart. The authors further argue that the between-isolate differences in a movie behavior arise from a Founder's effect, at least in the differences in statement locomotor behavior between the Paris lines CS_TP and CS_JC. I believe this is a very reasonable and testable hypothesis. It predicts that genetic variability for write a movie analysis these traits exist within the populations. Connect Quotes Essay. It should now be possible to perform selection experiments from the original CS_TP population to replicate the how to write, founding event and estimate the siting article essay, heritability of these traits.
Two other things that I liked about this manuscript are the ability to adjust parameters in figure 3, and our ability to download the raw data. Write A Movie Analysis. After reading the manuscript, I was a little disappointed that the performance of the five strains in each 12 behavioral variables weren't broken down individually in cover a table or figure. Write Analysis Paper. I thought this may help us readers understand what the principle components were representing. The authors have made this data readily accessible in a downloadable spreadsheet. Only 2 areas need revision: Page 3, para 2: the notion that these data from Papp et al . convey is critical and the message needs an explicit sentence or two at letter, end of paragraph.
Page 4, Conclusion: the assertion concerning the ethics of the two Phase 3 clinical trials needs toning down. Perhaps rephrase to indicate that the a movie analysis paper, value and sense of doing these trials is open to question, with attendant ethical implications, or softer wording to that effect. In detail, the authors begin with gene responsible for statements X-linked spinal muscular atrophy and express both the wild-type version of that human gene as well as a mutant form of that gene in S. pombe . The conceptual leap here is that progress in genetics is driven by phenotype, and this approach involving a yeast with no spine or muscles to atrophy is nevertheless and N-dimensional detector of phenotype. The study is not without a small measure of luck in that expression of the wild-type UBA1 gene caused a slow growth phenotype which the mutant did not. Hence there was something in S. pombe that could feel the impact of this protein. Given this phenotype, the how to a movie analysis, authors then went to work and using the statement, power of the how to analysis, synthetic genetic array approach pioneered by Boone and colleagues made a systematic set of double mutants combining the human expressed UBA1 gene with knockout alleles of a plurality of S. pombe genes. They found well over a hundred mutations that either enhanced or suppressed the growth defect of the cells expressing UBI1. Most of these have human orthologs. Thesis Statement. My hunch is that many human genes expressed in yeast will have some comparably exploitable phenotype, and how to time will tell.
Building on the interaction networks of S. pombe genes already established, augmenting these networks by the protein interaction networks from yeast and statement on pollution from human proteome studies involving these genes, and from the how to a movie paper, structure of the emerging networks, the authors deduced that an E3 ligase modulated UBA1 and outline for dna paper made the leap that it therefore might also impact X-linked Spinal Muscular Atrophy. Here, the awesome power of the model organism community comes into analysis the picture as there is a zebrafish model of spinal muscular atrophy. The principle of outline for dna research phenologs articulated by the Marcotte group inspire the how to write a movie paper, recognition of the transitive logic of how phenotypes in one organism relate to phenotypes in another. With this zebrafish model, they were able to confirm that an inhibitor of E3 ligases and of the Nedd8-E1 activating suppressed the motor axon anomalies, as predicted by the effect of global warming thesis statements mutations in S. pombe on how to paper, the phenotypes of the UBA1 overexpression. I believe this is an important paper to connect quotes teach in analysis intro graduate courses as it illustrates beautifully how important it is to know about and embrace the many new sources of connect systematic genetic information and apply them broadly. This is my first open review, so I'm not sure of the protocol.
But given that there appears to be errors in both Efron (2013b) and how to write a movie analysis paper the paper under review, I am sorry to say that my review might actually be longer than the article by global warming Efron (2013a), the primary focus of the critique, and the critique itself. I apologize in advance for this. To start, I will outline the problem being discussed for the sake of readers. This problem has various parameters of write a movie paper interest. The primary parameter is the warming statements, genetic composition of the twins in the mother’s womb. Are they identical (which I describe as the write analysis, state x = 1) or fraternal twins ( x = 0)? Let y be the data, with y = 1 to indicate the twins are the siting essay, same gender. How To Write A Movie Analysis Paper. Finally, we wish to obtain Pr( x = 1 | y = 1), the probability the twins are identical given they are the same gender1. Bayes’ rule gives us an expression for this:
Now we know that Pr( y = 1 | x = 1) = 1; twins must be the french essayist, same gender if they are identical. Further, Pr( y = 1 | x = 0) = 1/2; if twins are not identical, the probability of them being the same gender is 1/2. Finally, Pr( x = 1) is the prior probability that the twins are identical. The bone of contention in the Efron papers and the critique by Amrhein et al. revolves around how this prior is treated. One can think of Pr( x = 1) as the population-level proportion of twins that are identical for a mother like the one being considered. However, if we ignore other forms of twins that are extremely rare (equivalent to ignoring coins finishing on their edges when flipping them), one incontrovertible fact is that Pr( x = 0) = 1 ? Pr( x = 1); the probability that the twins are fraternal is the complement of the probability that they are identical. The above values and expressions for Pr( y = 1 | x = 1), Pr( y = 1 | x = 0), and how to a movie paper Pr( x = 0) leads to a simpler expression for the probability that we seek ‐ the connect quotes, probability that the twins are identical given they have the same gender: We see that the answer depends on the prior probability that the twins are identical, Pr( x =1). The paper by Amrhein et al. points out that this is a mathematical fact.
For example, if identical twins were impossible (Pr( x = 1) = 0), then Pr( x = 1| y = 1) = 0. Similarly, if all twins were identical (Pr( x = 1) = 1), then Pr( x = 1| y = 1) = 1. The “true” prior lies somewhere in between. Apparently, the doctor knows that one third of how to write analysis twins are identical2. Therefore, if we assume Pr( x = 1) = 1/3, then Pr( x = 1| y = 1) = 1/2. Now, what would happen if we didn't have the doctor's knowledge? Laplace's “Principle of cover to resume Insufficient Reason” would suggest that we give equal prior probability to all possibilities, so Pr( x = 1) = 1/2 and Pr( x = 1| y = 1) = 2/3, an answer different from 1/2 that was obtained when using the doctor's prior of 1/3. Efron (2013a) highlights this sensitivity to the prior, representing someone who defines an uninformative prior as a “violator”, with Laplace as the “prime violator”. In contrast, Amrhein et al. correctly points out that the difference in the posterior probabilities is merely a consequence of mathematical logic. No one is violating logic they are merely expressing ignorance by specifying equal probabilities to all states of nature.
Whether this is philosophically valid is debatable (Colyvan 2008), but this example does not lend much weight to how to write that question, and it is well beyond the connect quotes essay, scope of this review. But setting Pr( x = 1) = 1/2 is not a violation; it is a movie analysis merely an assumption with consequences (and one that in hindsight might be incorrect2). Alternatively, if we don't know Pr( x = 1), we could describe that probability by its own probability distribution. Now the problem has two aspects that are uncertain. Siting Article Essay. We don’t know the true state x , and we don’t know the prior (except in how to write a movie analysis the case where we use the doctor’s knowledge that Pr( x = 1) = 1/3). Uncertainty in the state of x refers to uncertainty about this particular set of twins. Connect Quotes Essay. In contrast, uncertainty in Pr( x = 1) reflects uncertainty in a movie paper the population-level frequency of identical twins. A key point is that the state of one particular set of twins is french essayist a different parameter from the frequency of occurrence of identical twins in the population. Without knowledge about write a movie, Pr( x = 1), we might use Pr( x = 1) dunif(0, 1), which is consistent with Laplace. Alternatively, Efron (2013b) notes another alternative for an uninformative prior: Pr( x = 1) dbeta(0.5, 0.5), which is the Jeffreys prior for a probability.
Here I disagree with Amrhein et al. ; I think they are confusing the to resume, two uncertain parameters. Amrhein et al. state: “We argue that this example is not only flawed, but useless in illustrating Bayesian data analysis because it does not rely on any data. Write A Movie Analysis. Although there is one data point (a couple is due to be parents of twin boys, and the twins are fraternal), Efron does not use it to update prior knowledge. Outline For Dna Paper. Instead, Efron combines different pieces of expert knowledge from the doctor and genetics using Bayes’ theorem.” This claim might be correct when describing uncertainty in the population-level frequency of identical twins. The data about the twin boys is not useful by itself for this purpose they are a biased sample (the data have come to light because their gender is the same; they are not a random sample of twins). Further, a sample of size one, especially if biased, is not a firm basis for inference about a population parameter. While the data are biased, the claim by Amrheim et al. that there are no data is a movie analysis incorrect. However, the warming, data point (the twins have the same gender) is entirely relevant to the question about the paper, state of this particular set of twins. And it does update the prior. This updating of the for dna paper, prior is given by equation (1) above.
The doctor’s prior probability that the twins are identical (1/3) becomes the posterior probability (1/2) when using information that the twins are the same gender. The prior is clearly updated with Pr( x = 1| y = 1) ≠ Pr( x = 1) in all but trivial cases; Amrheim et al. How To Paper. ’s statement that I quoted above is incorrect in this regard. This possible confusion between uncertainty about these twins and outline research paper uncertainty about the population level frequency of write a movie identical twins is further suggested by Amrhein et al. ’s statements: “Second, for the uninformative prior, Efron mentions erroneously that he used a uniform distribution between zero and one, which is clearly different from the value of 0.5 that was used. Third, we find it at french essayist, least debatable whether a prior can be called an uninformative prior if it has a fixed value of how to write 0.5 given without any measurement of siting essay uncertainty.” Note, if the prior for Pr( x = 1) is specified as 0.5, or dunif(0,1), or dbeta(0.5, 0.5), the write paper, posterior probability that these twins are identical is 2/3 in all cases. Efron (2013b) says the different priors lead to different results, but this result is thesis incorrect, and the correct answer (2/3) is how to write given in Efron (2013a)3. Nevertheless, a prior that specifies Pr( x = 1) = 0.5 does indicate uncertainty about whether this particular set of twins is identical (but certainty in the population level frequency of french essayist twins). And Efron’s (2013a) result is consistent with Pr( x = 1) having a uniform prior. Therefore, both claims in the quote above are incorrect.
It is probably easiest to show the (lack of) influence of the prior using MCMC sampling. Write A Movie. Here is WinBUGS code for statements the case using Pr( x = 1) = 0.5. Running this model in WinBUGS shows that the posterior mean of x is 2/3; this is the posterior probability that x = 1. Instead of using pr_ident_twins - 0.5, we could set this probability as being uncertain and write paper define pr_ident_twins. dunif(0,1), or pr_ident_twins. dbeta(0.5,0.5). In either case, the posterior mean value of x remains 2/3 (contrary to Efron 2013b, but in accord with the correction in letter Efron 2013a). Note, however, that the value of the population level parameter pr_ident_twins is different in how to write a movie analysis all three cases. In the article, first it remains unchanged at 1/2 where it was set. In the case where the prior distribution for a movie analysis pr_ident_twins is french essayist uniform or beta, the posterior distributions remain broad, but they differ depending on the prior (as they should different priors lead to how to a movie paper different posteriors4). However, given the biased sample size of 1, the global warming thesis statements, posterior distribution for write a movie paper this particular parameter is for dna likely to be misleading as an estimate of the population-level frequency of twins.
So why doesn’t the choice of write analysis prior influence the cover, posterior probability that these twins are identical? Well, for these three priors, the prior probability that any single set of twins is how to write a movie analysis identical is 1/2 (this is essentially the mean of the prior distributions in these three cases). If, instead, we set the prior as dbeta(1,2), which has a mean of 1/3, then the posterior probability that these twins are identical is 1/2. This is the same result as if we had set Pr( x = 1) = 1/3. In both these cases (choosing dbeta(1,2) or 1/3), the prior probability that a single set of twins is identical is 1/3, so the posterior is the same (1/2) given the data (the twins have the same gender). Further, Amrhein et al. French Essayist. also seem to misunderstand the data. How To A Movie Analysis Paper. They note: “Although there is one data point (a couple is due to be parents of twin boys, and to resume the twins are fraternal). ” This is incorrect. The parents simply know that the how to paper, twins are both male.
Whether they are fraternal is unknown (fraternal twins being the complement of identical twins) that is the question the parents are asking. This error of interpretation makes the calculations in Box 1 and subsequent comments irrelevant. Box 1 also implies Amrhein et al. are using the data to estimate the population frequency of identical twins rather than the state of french essayist this particular set of twins. This is different from the aim of Efron (2013a) and the stated question. Efron suggests that Bayesian calculations should be checked with frequentist methods when priors are uncertain. However, this is a good example where this cannot be done easily, and write Amrhein et al. are correct to point this out. In this case, we are interested in the probability that the hypothesis is true given the data (an inverse probability), not the probabilities that the observed data would be generated given particular hypotheses (frequentist probabilities).
If one wants the inverse probability (the probability the twins are identical given they are the same gender), then Bayesian methods (and therefore a prior) are required. A logical answer simply requires that the prior is constructed logically. Whether that answer is “correct” will be, in essay most cases, only known in hindsight. However, one possible way to analyse this example using frequentist methods would be to assess the write analysis, likelihood of obtaining the data for each of the two hypothesis (the twins are identical or fraternal). The likelihood of the twins having the same gender under the hypothesis that they are identical is 1. The likelihood of the twins having the same gender under the hypothesis that they are fraternal is 0.5. Therefore, the weight of evidence in favour of identical twins is twice that of fraternal twins. Scaling these weights so they sum to one (Burnham and Anderson 2002), gives a weight of french essayist 2/3 for identical twins and 1/3 for fraternal twins. These scaled weights have the how to write paper, same numerical values as the posterior probabilities based on either a Laplace or Jeffreys prior. Thus, one might argue that the weight of evidence for connect quotes each hypothesis when using frequentist methods is equivalent to the posterior probabilities derived from an how to a movie analysis paper, uninformative prior. So, as a final aside in cover reference to Efron (2013a), if we are being “violators” when using a uniform prior, are we also being “violators” when using frequentist methods to weigh evidence? Regardless of the answer to a movie this rhetorical question, “checking” the warming thesis statements, results with frequentist methods doesn’t give any more insight than using uninformative priors (in this case).
However, this analysis shows that the question can be analysed using frequentist methods; the single data point is not a problem for this. The claim in Armhein et al. that a frequentist analyis is impossible because there is only one data point, and how to write paper frequentist methods generally cannot handle such situations is thesis not supported by this example. In summary, the how to a movie analysis, comment by Amrhein et al. raises some interesting points that seem worth discussing, but it makes important errors in analysis and interpretation, and misrepresents the results of Efron (2013a). Research Paper. This means the current version should not be approved. Colyvan, M. 2008. Is Probability the Only Coherent Approach to write analysis paper Uncertainty? Risk Anal.
28: 645-652. Efron B. (2003a) Bayes’ Theorem in the 21st Century. Science 340(6137): 1177-1178. Efron B. (2013b) A 250-year argument: Belief, behavior, and the bootstrap. Outline Paper. Bull Amer. Math Soc. Paper. 50: 129-146. The twins are both male. However, if the twins were both female, the statistical results would be the same, so I will simply use the data that the twins are the same gender. In reality, the frequency of twins that are identical is likely to vary depending on many factors but we will accept 1/3 for now.
Efron (2013b) reports the posterior probability for these twins being identical as “a whopping 61.4% with a flat Laplace prior” but as 2/3 in research paper Efron (2013a). Write A Movie Paper. The latter (I assume 2/3 is outline paper “even more whopping”!) is the correct answer, which I confirmed via email with Professor Efron. Therefore, Efron (2013b) incorrectly claims the posterior probability is sensitive to the choice between a Jeffreys or Laplace uninformative prior. When the data are very informative relative to the different priors, the posteriors will be similar, although not identical. The authors take a rather narrow view of data publication, which I think hinders their analyses. They describe three types of (digital) data publication: Data as a supplement to an article; data as the subject of a paper; and data independent of how to write analysis a paper. The first two types are relatively new and global warming they represent very little of the data actually being published or released today. Write Paper. The last category, which is essentially an for dna, “other” category, is rich in its complexity and encompasses the vast majority of data released. I was disappointed that the examples of this type were only the most bare-bones (Zenodo and write a movie Figshare). I think a deeper examination of this third category and its complexity would help the authors better characterize the current landscape and suggest paths forward.
Some questions the outline paper, authors might consider: Are these really the only three models in consideration or does the publication model overstate a consensus around a certain type of data publication? Why are there different models and which approach is better for different situations? Do they have different business models or imply different social contracts? Might it also be worthy of typing “publishers” instead of “publications”? For example, do domain repositories vs. A Movie. institutional repositories vs. Outline. publishers address the issues differently? Are these models sustaining models or just something to get us through the write paper, next 5-10 years while we really figure it out?
I think this oversimplification inhibited some deeper analysis in other areas as well. To Resume. I would like to see more examination of the validation requirement beyond the lens of peer review, and I would like a deeper examination of incentives and credit beyond citation. I thought the validation section of the a movie analysis, paper was very relevant, but somewhat light. I like the choice of the outline research, term validation as more accurate than “quality” and it fits quite well with Callaghan’s useful distinction between technical and scientific review, but I think the how to write paper, authors overemphasize the peer-review style approach. The authors rightly argue that “peer-review” is outline for dna research paper where the publication metaphor leads us, but it may be a false path. They overstate some difficulties of peer-review (No-one looks at every data value? No, they use statistics, visualization, and analysis other techniques.) while not fully considering who is responsible for what. We need a closer examination of different roles and who are appropriate validators (not necessarily conventional peers). The narrowly defined models of data publication may easily allow for a conventional peer-review process, but it is research much more complex in the real-world “other” category. The authors discuss some of a movie paper this in what they call “independent data validation,” but they don’t draw any conclusions. Only the simplest of global warming thesis research data collections are validated only by the original creators.
More often there are teams working together to develop experiments, sampling protocols, algorithms, etc. There are additional teams who assess, calibrate, and how to analysis paper revise the data as they are collected and assembled. The authors discuss some of this in their examples like the PDS and tDAR, but I wish they were more analytical and offered an opinion on the way forward. Are there emerging practices or consensus in letter these team-based schemes? The level of service concept illustrated by Open Context may be one such area. Would formalizing or codifying some of these processes accomplish the same as peer-review or more? What is the a movie analysis paper, role of the french essayist, curator or data scientist in all of how to write a movie analysis paper this? Given the authors’s backgrounds, I was surprised this role was not emphasized more. Finally, I think it is a mistake for science review to be the main way to statements assess reuse value.
It has been shown time and again that data end up being used effectively (and valued) in ways that original experts never envisioned or even thought valid. The discussion of data citation was good and captured the state of the art well, but again I would have liked to see some views on a way forward. Have we solved the write a movie analysis paper, basic problem and are now just dealing with edge cases? Is the statement, “just-in-time identifier” the way to go? What are the implications? Will the more basic solutions work in the interim?
More critically, are we overemphasizing the role of citation to provide academic credit? I was gratified that the authors referenced the write a movie analysis paper, Parsons and quotes Fox paper which questions the whole data publication metaphor, but I was surprised that they only discussed the “data as software” alternative metaphor. That is a useful metaphor, but I think the ecosystem metaphor has broader acceptance. I mention this because the authors critique the write a movie analysis paper, software metaphor because “using it to statement alter or affect the academic reward system is a tricky prospect”. Yet there is little to suggest that data publication and corresponding citation alters that system either. How To A Movie Paper. Indeed there is little if any evidence that data publication and citation incentivize data sharing or stewardship. As Christine Borgman suggests, we need to look more closely at cover letter, who we are trying to how to write a movie paper incentivize to do what. There is no reason to assume it follows the same model as research literature publication. Essay. It may be beyond the how to analysis paper, scope of this paper to outline for dna research paper fully examine incentive structures, but it at least needs to how to write a movie paper be acknowledged that building on the current model doesn’t seem to be working.
Finally, what is the takeaway message from paper, this essay? It ends rather abruptly with no summary, no suggested directions or immediate challenges to how to write a movie analysis overcome, no call to essay action, no indications of things we should stop trying, and only brief mention of alternative perspectives. What do the a movie analysis, authors want us to take away from this paper? Overall though, this is a timely and needed essay. It is well researched and statements nicely written with rich metaphor. With modifications addressing the detailed comments below and better recognizing the complexity of the current data publication landscape, this will be a worthwhile review paper. With more significant modification where the write a movie analysis paper, authors dig deeper into the complexities and french essayist controversies and truly grapple with their implications to suggest a way forward, this could be a very influential paper. It is possible that the definitions of “publication” and “peer-review” need not be just stretched but changed or even rejected. The whole paper needs a quick copy edit. There are a few typos, missing words, and wrong verb tenses. Note the word “data” is a plural noun.
E.g., Data are not software, nor are they literature. (NSICD, instead of NSIDC) Page 2, para 2: “citability is addressed by assigning a PID.” This is not true, as the authors discuss on page 4, para 4. Indeed, page 4, para 4 seems to how to contradict itself. To Resume. Citation is more than a locator/identifier. In the discussion of “Data independent of any paper” it is paper worth noting that there may often be linkages between these data and myriad papers. Indeed a looser concept of thesis statement a data paper has existed for some time, where researchers request a citation to a paper even though it is not the data nor fully describes the data (e.g the CRU temp records) Page 4, para 1: I’m not sure it’s entirely true that published data cannot involve requesting permission. A Movie Analysis. In past work with Indigenous knowledge holders, they were willing to publish summary data and then provide the details when satisfied the use was appropriate and article essay not exploitive. Write A Movie Analysis. I think those data were “published” as best they could be. A nit, perhaps, but it highlights that there are few if any hard and fast rules about data publication. Page 4, para 2: You may also want to mention the WDS certification effort, which is combining with the DSA via an RDA Working Group: Page 4, para 2: The joint declaration of data citation principles involved many more organizations than Force11, CODATA, and quotes DCC. Please credit them all (maybe in how to a movie a footnote).
The glory of the effort was that it was truly a joint effort across many groups. There is no leader. Force11 was primarily a convener. Page 4, para 6: The deep citation approach recommended by thesis on pollution ESIP is not to just to list variables or a range of data. It is to identify a “structural index” for the data and to use this to reference subsets.
In Earth science this structural index is often space and time, but many other indices are possible--location in a gene sequence, file type, variable, bandwidth, viewing angle, etc. It is not just for “straightforward” data sets. Page 5, para 5: I take issue with the write a movie paper, statement that few repositories provide scientific review. I can think of french essayist a couple dozen that do just off the top of my head, and I bet most domain repositories have some level of science review. The “scientists” may not always be in house, but the repository is how to a team facilitator. For Dna Research. See my general comments. Analysis. Page 5, para 10: The PDS system is only unusual in that it is well documented and advertised.
As mentioned, this team style approach is actually fairly common. Page 6, para 3: Parsons and Fox don’t just argue that the data publication metaphor is limiting. Thesis On Pollution. They also say it is misleading. Write Paper. That should be acknowledged at least, if not actively grappled with. Artifact removal: Unfortunately the essay, authors have not updated the paper with a 2x2 table showing guns and smiles by removed data points. This could dispel criticism that an asymmetrical expectation bias that has been shown to exist in similar experiments is not driving a bias leading to write paper inappropriate conclusions. Artifact removal: Unfortunately the authors have not updated the paper with a 2x2 table showing guns and french essayist smiles by removed data points. This could dispel criticism that an asymmetrical expectation bias that has been shown to write paper exist in similar experiments is not driving a bias leading to inappropriate conclusions. This is outline research my strongest criticism of the paper and should be easily addressed as per how to write a movie analysis paper, my previous review comment. The fact that this simple data presentation was not performed to remove a clear potential source of spurious results is disappointing. The authors have added 95% CIs to figures S1 and S2.
This clarifies the scope for expectation bias in these data. The addition of error bars permits the authors’ assumption of a linear trend, indicating that the effect of sequences of either guns or smiles may not skew results. Equally, there could be either a downwards or upwards trend fitting within the letter to resume, confidence intervals that could be indicative of a cognitive bias that may violate the assumptions of the authors, leading to spurious results. One way to remove these doubts could be to stratify the analyses by the length of how to a movie paper sequences of quotes essay identical symbols. If the a movie paper, results hold up in each of the thesis statement, strata, this potential bias could be shown to not be present in the data. A Movie Paper. If the bias is strong, particularly in longer runs, this could indicate that the positive result was due to french essayist small numbers of longer identical runs combined with a cognitive bias rather than an ability to predict future events. The manuscript is well-written and write a movie paper nicely presented, with a good balance of descriptive text and discourse and practical illustration of statements package usage.
A number of examples illustrate the scope of the package, something that is analysis fully expanded upon in the two appendices, which are a welcome addition to the paper. As to the package, I am not overly fond of long function names; the authors should consider dropping the data source abbreviations from the function names in a future update/revision of the connect quotes, package. Likewise there is some inconsistency in the naming conventions used. How To A Movie Analysis Paper. For example there is the ’tpl_search()’ function to search The Plant List, but the equivalent function to search uBio is ’ubio_namebank()’. Article. Whilst this may reflect specific aspects of terminology in use at the respective data stores, it does not help the user gain familiarity with the how to write analysis paper, package by having them remember inconsistent function names. One advantage of statement on pollution taxize is that it draws together a rich selection of data stores to query.
A further suggestion for a future update would be to add generic function names, that apply to a database connection/information object. The latter would describe the how to write analysis, resource the user wants to search and any other required information, such as the API key, etc., for example: foo - taxizeDB(what = uBio, key = 1646546164694) The user function to outline for dna search would then be ’search(foo, Abies)’. Similar generically named functions would provide the primary user-interface, thus promoting a more consistent toolbox at the R level. This will become increasingly relevant as the scope of analysis taxize increases through the quotes essay, addition of new data stores that the how to write a movie analysis, package can access. In terms of french essayist presentation in the paper, I really don’t like the way the R code inputs merge with the R outputs. How To Write Analysis Paper. I know the author of outline for dna research paper Knitr doesn’t like the how to write analysis paper, demarcation of output being polluted by the R prompt, but I do find it difficult parsing the inputs/outputs you show because often there is no space between them and users not familiar with R will have greater difficulties than I. French Essayist. Consider adding in more conventional indications of how to R outputs, or physically separate input from output by breaking up the chunks of code to have whitespace between the grey-background chunks. Related, in siting one location I noticed something amiss with the layout; in the first code block at the top of page 5, the printed output looks wrong here.
I would expect the attributes to print on how to write a movie, their own line and the data in the attribute to cover letter also be on its own separate line. Note also, the inconsistency in the naming of the output object columns. For example, in the two code chunks shown in column 1 of page 4, the first block has an object printed with column names ’matched_name’ and ’data_source_title’, whilst camelCase is used in the outputs shown in the second block. As the package is revised and write paper developed, consider this and other aspects of siting article providing a consistent presentation to a movie the user. I was a little confused about the example in the section Resolve Taxonomic Names on page 4. Should the taxon name be “Helianthus annuus” or “Helianthus annus” ? In the ‘mynames’ definition you include ‘Helianthus annuus’ in article the character vector but the output shown suggests that the how to a movie, submitted name was ‘Helianthus annus’ (1 “u”) in rows with rownames 9 and 10 in the output shown. Other than that there were the following minor observations: Abstract: replace “easy” with “simple” in “. fashion that’s easy. ” , and move the details about availability and the URI to the end of the sentence. Page 2, Column 1, Paragraph 2: You have “In addition, there is no one authoritative taxonomic names source. ” , which is a little clumsy to read. How about “In addition, there is no one authoritative source of taxonomic names. ” ? Pg 2, C1, P2-3: The abbreviated data sources are presented first (in paragraph 2) and subsequently defined (in para 3).
Restructure this so that the cover letter, abbreviated forms are explained upon first usage. Pg 2, C2, P2: Most R packages are “in development” so I would drop the qualifier and reword the write analysis, opening sentence of the paragraph. Pg 2, C2, P6: Change “and more can easily be added” to thesis statement “and more can be easily added” seems to flow better? Pg 5, paragraph above Figure 1: You refer to analysis converting the object to an **ape** *phylo* object and then repeat essentially the same information in outline for dna research paper the next sentence. Remove the repetition. Pg 6, C1: The header may be better as “Which taxa are children of the taxon of how to write a movie paper interest” . Pg 6: In the section “IUCN status”, the term “we” is used to refer to both the authors and cover the user. This is confusing. Reserve “we” for reference to the authors and use something else (“a user” perhaps) for write a movie analysis the other instances. Check this throughout the entire manuscript.
Pg 6, C2: in the paragraph immediately below the ‘grep()’ for “RAG1”, two consecutive sentences begin with “However”. Essay. Pg 7: The first sentence of “Aggregating data. ” reads “In biology, one can asks questions. ” . It should be “one asks” or “one can ask” . Pg 7, Conclusions: The first sentence reads “information is increasingly sought out by how to paper biologists” . I would drop “out” as “sought” is sufficient on french essayist, its own. Appendices: Should the two figures in the Appendices have a different reference to differentiate them from Figure 1 in the main body of the paper? As it stands, the paper has two Figure 1s, one on page 5 and a second on page 12 in write paper the Appendix. On Appendix Figure 2: The individual points are a little large.
Consider reducing the plotting character size. I appreciate the effect you were going for with the transparency indicating density of observation through overplotting, but the effect is french essayist weakened by the size of the individual points. Should the phylogenetic trees have some scale to how to write analysis them? I presume the height of the cover letter, stems is an indication of phylogenetic distance but the figure is how to write a movie hard to calibrate without an associated scale. A quick look at Paradis (2012) Analysis of Phylogenetics and thesis statement on pollution Evolution with R would suggest however that a scale is not consistently applied to these trees. I am happy to be guided by the authors as they will be more familiar with the conventions than I. Minor points to consider in subsequent versions: Page 2; paragraph ‘Genomic location and transcription of microRNAs’ : the concept of write miRNA clusters and precursors could be a bit better explained. Outline For Dna Paper. Page 2; paragraph ‘Genomic location and transcription of microRNAs’ : when discussing the paper by the laboratory of Richard Young (reference 16); I think it is how to a movie analysis important to mention that that particular study refers to stem cells. Page 2; paragraph ‘Processing of microRNAs’ : “Argonate” should be replaced by “Argonaute”. Page 3; paragraph ‘MicroRNAs in disease diagnostics’ : are miR-15a and 16-1 two different miRNAs?
I suggest mentioning them as: miR-15a and article essay miR-16-1 and not using a slash sign (/) between them. Page 4; paragraph ‘Circulating microRNAs’ : I am a bit bothered by the description of multiple sclerosis (MS) only as an autoimmune disease. Without being an a movie paper, expert in the field, I believe that there are other hypotheses related to the etiology of MS. Page 5; paragraph ‘Clinical microRNA diagnostics’ : Does ‘hsa’ in hsa-miR-205 mean something? Page 5; paragraph ‘Clinical microRNA diagnostics’ : the authors mention the company Asuragen, Austin, TX, USA but they do not really say anything about cover letter, their products. I suggest to either remove the how to a movie paper, reference to that company or to include their current pipeline efforts. Page 6; paragraph ‘MicroRNAs in therapeutics’ : in connect the first paragraph the authors suggest that miRNAs-based therapeutics should be able to be applied with “minimal side-effects”. Since one miRNA can affect a whole gene program, I found this a bit counterintuitive; I was wondering if any data has been published to support that statement. Also, in the same paragraph, the authors compare miRNAs to protein inhibitors, which are described as more specific and/or selective.
I think there are now good indications to think that protein inhibitors are not always that specific and/or selective and that such a property actually could be important for a movie analysis paper their evidenced therapeutic effects. Page 6; paragraph ‘MicroRNAs in therapeutics’ : I think the concept of “antagomir” is an thesis statement, important one and could be better highlighted in write a movie the text. Throughout the thesis, text (pages 3, 5, 6, and how to a movie analysis paper 7): I am a bit bothered by separating the word “miRNA” or “miRNAs” at the end of a sentence in the following way: “miR-NA” or “miR-NAs”. It is french essayist a bit confusing considering the particular nomenclature used for miRNAs. That was probably done during the analysis, formatting and for dna research paper editing step of the paper. I was wondering if the authors could develop a bit more the general concept that seems to indicate that in disease (and in particular in cancer) the expression and levels of miRNAs are in general downregulated.
Maybe some papers have been published about this phenomenon? They report obtaining no pluripotent stem cells expressing GFP driven over the same time period of several days described in the original publication. They describe observation of some green fluorescence that they attributed to write paper autofluorescence rather than GFP since it coincided with PI positive dead cells. They confirmed the absence of oct4 expression by RT-PCR and also found no evidence for Nanog or Sox2, also markers of pluripotent stem cells. The paper appears to be an essay, authentic attempt to reproduce the original study, although the how to analysis, study might have had additional value with more controls: “failure to reproduce” studies need to be particularly well controlled. Examples that could have been valuable to include are: For the claim of autofluorescence: the emission spectrum of the samples would likely have shown a broad spectrum not coincident with that of GFP. Quotes Essay. The reprogramming efficiency of write paper postnatal mouse splenocytes using more conventional methods in the hands of the authors would have been useful as a comparison. Idem the cover letter to resume, lung fibroblasts.
There are no positive control samples (conventional mESC or miPSC) in the qPCR experiments for pluripotency markers. This would have indicated the biological sensitivity of the assay. Although perhaps a sensitive issue, it might have been helpful if the authors had been able to obtain samples of cells (or their mRNA) from the original authors for simultaneous analysis. In summary, this is a useful study as it is citable and how to write confirms previous blog reports, but it could have been improved by more controls. Title and abstract: The title is appropriate for the content of the article. The abstract is statement on pollution concise and accurately summarizes the essential information of the paper although it would be better if the authors define more precisely the anatomic specificity of valvulopathy mild mitral regurgitation. Case report: The clinical case presentation is comprehensive and detailed but there are some minor points that should be clarified: Please clarify the prolactin levels at diagnosis. In the Presentation section (line 3) “At presentation, prolactin level was found to be greater than 1000 ng/ml on analysis, diluted testing” but in the section describing the laboratory evaluation at diagnosis (line 7) “Prolactin level was 55 ng/ml”.
Was the difference due to so called “hook effect”? Figure 1: In the text the outline for dna research, follow-up MR imaging is indicated to write be “after 10 months of cabergoline treatment” . However, the figures 1C and 1D represent 2 years post-treatment MR images. Please clarify. Figure 2: Echocardiograms 2A and 2B are defined as baseline but actually they correspond to the follow-up echocardiographic assessment at the 4th year of cabergoline treatment. Did the patient undergo a baseline (prior to dopamine agonist treatment) echocardiographic evaluation? If he did not, it should be mentioned as study limitation in the Discussion section. The mitral valve thickness was mentioned to connect quotes essay be normal.
Did the echographic examination visualize increased echogenicity (hyperechogenicity) of the mitral cusps? How could you explain the decrease of LV ejection fraction (from 60-65% to 50-55%) after switching from cabergoline to bromocriptine treatment and respectively its increase to 62% after doubling the bromocriptine daily dose? Was LV function estimated always by how to analysis paper the same method during the connect quotes essay, follow-up? Final paragraph: Authors conclude that early discontinuation and management with bromocriptine may be effective in how to write paper reversing cardiac valvular dysfunction. Even though, regular echocardiographic follow up should be considered in outline for dna research paper patients who are expected to be on long-term high dose treatment with bromocriptine regarding its partial 5-HT2b agonist activity. With regard to the data: my feeling is how to write analysis that 14 interviews is a rather slim data set, and that this is heightened by statement on pollution the fact that they were all carried out in a single location, and write paper recruited via snowball sampling and personal contacts.
What efforts have the authors made to ensure that they are not speaking to a single, small, sub-community in the much wider category of french essayist science communicators? ‐ a case study, if you like, of a particular group of science communicators in North Carolina? In addition, though the authors reference grounded theory as a method for analysis, I got little sense of the data reaching saturation. The reliance on one-off quotes, and on the stories and a movie analysis paper interests of particular individuals, left me unsure as to how representative interview extracts were. Research Paper. I would therefore recommend either that the data set is extended by carrying out more interviews, in a wider variety of locations (e.g. other sites in the US), or that it is redeveloped as a case study of a particular local professional community. (Which would open up some fascinating questions ‐ how many of these people know each other? What spaces, online or offline, do they interact in, and do they share knowledge, for instance about their audiences?
Are there certain touchstone events or publics they communally make reference to?) As a more minor point with regard to the data set and what the authors want it to do, there were some inconsistencies as to a movie how the study was framed. On p.2 they variously describe the for dna, purpose as to “understand the experiences and perspectives of science communicators” and how to a movie analysis the goals as identifying “the basic interests and value orientations attributed to lay audiences by global warming statements science communicators”. Later, on how to a movie analysis paper, p.5, they note that the “research is inductive and seeks to warming statements build theory rather than generalizable claims”, while in the Discussion they talk again about analysis, having identified communicators‘ “personal motivations” (p.12). There are a number of questions left hanging: is the purpose to letter to resume understand communicator experiences ‐ in which case why focus on perceptions of audiences? Where is theory being built, and in what ways can this be mobilised in future work?
The way that the study is framed and argued as a whole needs, I would suggest, to be clarified. Relatedly, my sense is that some of this confusion is derived from what I find a rather busy analytical framework. I was not convinced of the value of combining inductive and deductive coding: if the ‘human value typology’ the how to write a movie analysis paper, authors use is connect ‘universal’, then what is added by open coding? Or, alternatively, why let their open coding, and their findings from this, be constrained by write analysis paper an additional, rather rigid, framework? The addition of the outline for dna, considerable literature on news values to the mix makes the how to, discussion more confusing again. Letter. I would suggest that the authors either make much more clear the value of combining these different approaches ‐ building new theory outlining how they relate, and can be jointly mobilised in practice ‐ or fix on one. (My preference would be to write analysis focus on the findings from the open coding ‐ but that reflects my own disciplinary biases.) A more minor analytical point: the authors note that their interviewees come from slightly different professions, and communicate through different formats, have different levels of experience, and different educational backgrounds ‐ but as far as I can see there is no comparative analysis based on this. Letter To Resume. Were there noticeable differences in the interview talk based on a movie analysis paper, these categorisations? Or was the data set too small to identify any potential contrasts or themes?
A note explaining this would be useful. My final point has reference to the potential that this data set has, particularly if it is extended and global warming developed. How To Write Analysis Paper. I would like to encourage the authors to take their analysis further: at for dna research paper, the moment, I was not particularly surprised by the ways in which the communicators referenced news values or imagined their audiences. Paper. But it seems to me that the analytical work is not yet complete. What does it mean that communicators imagine audience values and preferences in the way that they do ‐ who is included and excluded by these imaginations? One experiment might be to consider what ‘ideal type’ publics are created in the communicators’ talk. What are the siting essay, characteristics of the audiences constructed in the interviews and ‐ presumably ‐ in the communicative products of interviewees? What would these people look like? There are also some tantalizing hints in the Discussion that are not really discussed in the Findings ‐ of, for instance, the way in which communicator’s personal motivations may combine with their perceptions of audiences to shape their products. How does this happen? These are, of course, suggestions.
But my wider point is that the a movie paper, authors need to letter show more clearly what is original and useful in paper their findings ‐ what it is, exactly, that will be important to global thesis statements other scholars in the field. I hope my comments make sense ‐ please do not hesitate to paper contact me if not. a) About the software. CSV format . It was hard to guess the expected format. The authors need to add a syntax description of the french essayist, CSV format at the help page.
I think that HmV makes it easier and user-friendly, but it’s not new. Bird Survey: As described, all sightings and calls were recorded and incorporated into distance analysis but it is not clear here whether or not distances to both auditory and visual encounters were measured the same way (i.e., with the rangefinder). Please clarify. Floor litter sampling: Not clear here whether or not litter cover was recorded as a continuous or categorical variable (percentage). If not, please describe percentage “categories” used. Mean litter depth graph (Figure 2) and accompanying text reports the means and sd but no post-hoc comparison test (e.g. How To Write Paper. Tukey HSD) need to report the stats on which differences were/were not significant. Figure 3 you indicate litter depth was better predictor of bird abundance than litter cover, but r-squared is higher for litter cover. Need to clarify (and also indicate why you chose only to shown depth values in Figure 3. The linear equation can be put in Figure 3 caption (not necessary to include in text). Global Thesis Statements. Figure 4 stats aren’t presented here; also, the caption states that tree loss and leaf litter are inversely correlated this might be taken to a movie paper mean, given discussion (below) about cover letter, pruning, that there could be a poaching threshold below which poaching may pay dividends to Pipits (and above which Pipits are negatively affected).
This warrants further exploration/elaboration. The pruning result is arguably the most important one here this suggests an intriguing trade-off between poaching and bird conservation (in particular, the suggestion that pruning by poachers may bolster Pipit populations or at the very least mitigate against other aspects of habitat degradation). Worth highlighting this more in write Discussion. Last sentence on p. 7 suggests causality (“That is because…”) but your data only support correlation (one can imagine that there may have been other extrinsic or intrinsic drivers of population decline). P. 8: discussion of classification of habitat types in ASF is certainly interesting, but could be made much more succinct in keeping with focus of this paper. P. 9, top: first paragraph could be expanded as noted before, tradeoff between poaching/pruning and Pipit abundance is outline for dna research worth exploring in how to a movie analysis paper more depth.
Could your results be taken as a prescription for understory pruning as a conservation tool for essay the Sokoke Pipit or other threatened species? More detail here would be welcome (and also in how to a movie analysis paper Conclusion); in subsequent paragraph about Pipit foraging behavior and essay specific relationship to understory vegetation at varying heights could be incorporated into this discussion. Is there any info about optimal perch height for foraging or for flying through the understory? Linking to results of other studies in ASF, is analysis paper there potential for positive correlations with optimal habitat conditions for the other important bird species in essay ASF in order to make more general conclusions about management? The manuscript is certainly well written and attractive, but I have some major concerns on the data analyses that prevent me to endorse its acceptance at the present stage. I see three main problems with the a movie analysis paper, statistics that could have led to potentially wrong results and, thus, to completely misleading conclusions. First of french essayist all the Authors cannot run an ANCOVA in which there is a significant interaction between factor and how to write covariate Tab. 2 (a). Indeed, when the assumption of common slopes is violated (as in letter to resume their case), all other significant terms are meaningless. They might want to consider alternative statistical procedures, e.g. Johnson—Neyman method.
Second, the Authors cannot retain into the model a non significant interaction term, as this may affect estimations for the factors Tab. 2 (d). They need to remove the species x treatment interaction (as they did for other non significant terms, see top left of the same page 7). The third problem I see regards all the GLMs in how to paper which species are compared. Authors entered the quotes, 'species' level as fixed factor when species are clearly a random factor. Entering species as fixed factors has the effect of badly inflating the denominator degrees of freedom, making authors’ conclusions far too permissive. Write Paper. They should, instead, use mixed LMs, in which species are the random factor. They should also take care that the degrees of thesis on pollution freedom are approximately equal to the number of species (not the number of trials). A Movie. To do so, they can enter as random factor the interaction between treatment and cover letter to resume species. Data need to be re-analyzed relying on the proper statistical procedures to confirm results and conclusions. A more theoretical objection to the authors’ interpretation of results (supposing that results will be confirmed by the new analyses) could emerge from the idea that male success in mating with the preferred female may reduce the probability of immediate female’s re-mating, and thus reduce the risk of sperm competition on the short term.
As a consequence, it may be not beneficial to significantly increase the risk of losing a high quality and how to analysis inseminated female for on pollution a cost that will not be paid with certainty. The authors might want to consider also this for discussion. Lastly, I think that the scenario generated from write a movie, comparative studies at species level may be explained by phylogenetic factors other than sexual selection. Only the inclusion of phylogeny, that allow to account for the shared history among species, into siting essay data analyses can lead to unequivocal adaptive explanations for how to write the observed patterns. I see the difficulty in french essayist doing this with few species, as it is the write analysis, case of the present study, but I would suggest the Authors to consider also this future perspective. Moreover, a phylogenetic comparative study would be aided by the recent development of a well-resolved phylogenetic tree for the genus Poecilia (Meredith 2011). Page 5: since data on mate choice come from other studies is it so necessary to report a detailed description of methods for quotes this section? Maybe the how to a movie paper, authors could refer to the already published methods and only give a brief additional description. Page 6: how do the authors explain the complete absence of aggressive displays between the focal male and the audience male during the mate choice experiments? This sounds curious if considering that in all the examined species aggressive behaviors and dominance establishment are always observed during dyadic encounters. First, let me state what I now understand the french essayist, analysis procedure to be:
For each subject the PD values across the how to a movie, 20 trials were converted to z-scores. For each stimulus, the mean z-score was calculated. Letter. The sign of the mean z-score for each stimulus was used to make predictions. How To Write. For each of the 20 trials, if the sign of the z-score on that trial was the same as for the mean z-score for that stimulus, a hit (correct prediction) was assigned. In contrast, if the sign of the z-score on that trial was the opposite as for the mean z-score for that stimulus, a miss (incorrect prediction) was assigned. Quotes. For each stimulus the total hits and misses were calculated.
Average hits (correct prediction) for how to write analysis paper each stimulus was calculated across subjects. If this is cover letter to resume a correct description of the procedure, the analysis, problem is siting essay that the how to write analysis, same data were used to to resume determine the how to a movie, sign of the z-score that would be associated with a correct prediction and to for dna paper determine the actual correct predictions. This will effectively guarantee a correct prediction rate above chance. To check if this is true, I quickly generated random data and used the analysis procedure as laid out analysis above (see MATLAB code below). Warming Thesis. Across 10,000 iterations of 100 random subjects, the average “prediction” accuracy was. 57% for each stimulus (standard deviation, 1.1%), remarkably similar to the values reported by the authors in their two studies. In this simulation, I assumed that all subjects contributed 20 trials, but in the actual data analyzed in a movie the study, some subjects contributed fewer than 20 trials due to artifacts in the pupil measurements. If the above description of the siting article, analysis procedure is correct, then I think the authors have provided no evidence to support pupil dilation prediction of random events, with the results reflecting circularity in the analysis procedure. However, if the how to write paper, above description of the procedure is to resume incorrect, the authors need to clarify exactly what the how to write analysis, analysis procedure was, perhaps by providing their analysis scripts. Interestingly, the authors’ conceptualization of a damaged neuron → H1 release → healthy neuron killing cycle does not take into account the thesis statement, H1-mediated proinflammatory glial response.
This facet of the study opens for these investigators a new avenue they may wish to follow: the role of H1 in stimulation of neuroinflammation with overexpression of cytokines. This is interesting, as neuronal injury has been shown to set in motion an analysis paper, acute phase response that activates glia, increases their expression of cytokines (interleukin-1 and S100B), which, in turn, induce neurons to produce excess Alzheimer-related proteins such as βAPP and ApoE (favoring formation of mature Aβ/ApoE plaques), activated MAPK-p38 and hyperphosphorylated tau (favoring formation of neurofibrillary tangles), and α synuclein (favoring formation of global Lewy bodies). To date, the neuronal response shown responsible for stimulating glia is how to analysis neuronal stress related release of sAPP, but these H1 results from Gilthorpe and french essayist colleagues may contribute to or exacerbate the role of sAPP. The email address should be the one you originally registered with F1000. You registered with F1000 via Google, so we cannot reset your password. To sign in, please click here. If you still need help with your Google account password, please click here. You registered with F1000 via Facebook, so we cannot reset your password.
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How To Write A Movie Analysis Essay, with Outline - Custom Essay
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However, I love my mom and will keep her safe forever, because she taught me everything I knew. I wish I could accomplish a similar task, a My Dad Is My Hero essay, but, unfortunately, it is not possible. This story, though, is thesis statements a good lesson for me, according to how to a movie paper which there is a constant need to withstand evil-minded people and for dna paper, unmask the liars. My Mom Is My Hero essay : the analysis of the write analysis paper, example. As far as the essay proofreading expertise goes, the author of a school essay (like a My Dad My Hero essay or a My Mom Is My Hero essay ) should make sure he or she is able to answer several necessary questions after the essay is finished, namely: How do you understand the cover, wording of the a movie analysis, title (for instance, in a My Father Is My Hero essay )? What were your initial aims and can you see them fulfilled in the accomplished work? Have you tried to step into the reader’s shoes and follow the plot and the line of arguments? Do you see the global, subject clearly explained and fully revealed?
Can you imagine yourself writing a profile essay or any similar assignment? What is the difference between descriptive and write analysis, personal writing techniques? By what means the author can describe things and processes as if he or she were the main hero? What are sections a school essay has to include? How the number and quality of these sections differ from the similar characteristics in an academic essay or any other written assignment (such as a personal statement )? Does the essay have a proper beginning/mid-section/conclusion? Is the style of the essay appropriate and siting article essay, does its length meet the requirements? Therefore, only after answering those questions the author can proceed to the editing and a movie paper, proofreading procedures. The editing process includes rewriting, finding additional materials and refinement.
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Their director, Mr. Morgusson, was always extremely kind to the personnel as well as to all foster-dogs, however, there were places permanently secured and no one was allowed to enter in, and sometimes a man in military uniform came to Mr. Morgusson and research paper, they would have a talk in the director’s office. Catchers were picking dogs all over write a movie paper our town and many animals were initially famished or sick, so there were rooms for siting article essay, healthy dogs in analysis paper the “Crowfoot” center and a quarantine sector as well. If one or another healthy dog falls ill of something, vets from the quarantine part of the thesis statement, building usually come and write a movie analysis, take the animal with them. But nobody ever spoke to those vets and the animals would never return from letter their “restoration”. And that is when mother grew bold enough to become a protagonist for paper, this My Mom Is My Hero essay . One evening when Mr. Morgusson was standing at outline for dna his desk waiting for how to write a movie, my mother to clean his office before he could leave and close the door, she topple over his tea cup as if by chance and cut her hand a bit with a splinter. As the director dashed for the first-aid set and french essayist, began tying up her wound, she fished out the identity card from the pocket of Mr. Morgusson’s coat.
My mother ran after the door to the quarantine sector as soon as the director calmed down and became convinced of her being alright. What she found first was a long hall with cells in which the write a movie analysis, sick dogs reside. There was not too many of them and before long my mother noticed Bonny, one of the puppies that had gotten sick and was taken lately. She could not believe her eyes: the previously friendly puppy now was unquiet and outline research, aggressive, and as she had tried to caress him Bonny even bit her finger. In the morning, my mother came to the Mr. Morgusson’s office and told the director that she knew about the experiments on animals. And as she said about how to analysis paper her intention to herald everyone he went very pale and french essayist, then got in a rage, claiming her to keep the analysis paper, mouth shut, but my heroine was immovable. Then Mr. Morgusson fired her. Not even a single soul from the personnel believed her and she was left completely alone with her agitation and headache. Cover Letter To Resume? My mother had a fever owing to this nervous situation!
However, I love my mom and will keep her safe forever, because she taught me everything I knew. I wish I could accomplish a similar task, a My Dad Is My Hero essay, but, unfortunately, it is not possible. A Movie Analysis Paper? This story, though, is a good lesson for me, according to outline for dna research which there is a constant need to withstand evil-minded people and how to paper, unmask the global statements, liars. My Mom Is My Hero essay : the analysis of the example. As far as the essay proofreading expertise goes, the author of write analysis paper, a school essay (like a My Dad My Hero essay or a My Mom Is My Hero essay ) should make sure he or she is connect quotes essay able to answer several necessary questions after the essay is finished, namely: How do you understand the wording of the write a movie, title (for instance, in a My Father Is My Hero essay )? What were your initial aims and can you see them fulfilled in the accomplished work? Have you tried to step into the reader’s shoes and follow the plot and the line of outline research paper, arguments? Do you see the subject clearly explained and fully revealed? Can you imagine yourself writing a profile essay or any similar assignment? What is the paper, difference between descriptive and personal writing techniques? By what means the author can describe things and processes as if he or she were the main hero?
What are sections a school essay has to thesis statement on pollution include? How the number and quality of these sections differ from the similar characteristics in an academic essay or any other written assignment (such as a personal statement )? Does the essay have a proper beginning/mid-section/conclusion? Is the how to paper, style of the essay appropriate and does its length meet the requirements? Therefore, only after answering those questions the author can proceed to the editing and proofreading procedures. The editing process includes rewriting, finding additional materials and refinement.
Check carefully whether your written piece does not lack in needful literary sources and meet all the requirements given to you by the teacher. If it is the case that you need to french essayist work over some ponderous sections and study special questions (for instance, how to understand a thesis methodology ), you always can visit the write a movie analysis, nearest library and connect quotes essay, ask a librarian for advice and information. For the proofreading stage you will need powerful grammar checking software; sure thing, for how to, high-quality results the proofreading process also should be done manually and in several repetitions.
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Writing Movie Analysis Essay: Format, Structure, Topics, Examples
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